Male infertility treatment · Thanjavur
Sperm DNA fragmentation index (DFI)
A specialised semen test that measures damage to the genetic material in sperm, which a routine semen analysis does not show.
Dr. Sangeetha BalamuruganFertility Specialist & Reproductive Medicine Specialist
About the DFI test
Sperm DNA fragmentation refers to breaks or damage in the genetic material (DNA) carried by sperm. The DNA Fragmentation Index (DFI) is the percentage of sperm in a sample that have fragmented DNA.
Sperm can look normal in a routine semen analysis and still carry damaged DNA. High levels of DNA fragmentation have been associated in some studies with difficulty conceiving, poorer embryo development and miscarriage. At Skanda Fertility & Women's Health Centre, Thanjavur, the test is advised when the history suggests it may help guide treatment.
When the DFI test may be advised
The test may be useful in situations such as:
- Unexplained infertility
- Recurrent miscarriage
- Repeated unsuccessful IUI, IVF or ICSI
- Poor embryo development in previous IVF cycles
- Varicocele
- An abnormal semen analysis
- An older male partner, smoking, or exposure to heat or toxins
Your specialist will advise whether the test is likely to be useful for you.
What can affect sperm DNA
DNA fragmentation can be influenced by factors such as:
- Smoking and alcohol
- Infection or inflammation
- Varicocele
- Fever or recent illness
- Heat exposure
- Increasing age
- Excess weight
When fragmentation is high, the plan may include treating the cause, lifestyle changes, or choosing a particular treatment approach.
Book a consultationTreatments & care
Other treatments and care
Semen analysisThe basic test of male fertility: sperm count, movement and shape.
ICSIA single sperm is injected directly into an egg to help overcome certain male and female fertility challenges.
IVFIn-vitro fertilisation with personalised care and monitoring through every stage of treatment.
IUIA minimally invasive treatment that places prepared sperm in the uterus around the time of ovulation.
Sperm freezingSperm frozen and stored for later use in IUI, IVF or ICSI.
Surgical sperm retrievalSperm collected directly from the testis or epididymis for ICSI when none are in the ejaculate.
MESA / TESAMESA from the epididymis or TESA from the testis, to retrieve sperm for ICSI.
Embryo freezingEmbryos from an IVF or ICSI cycle frozen and stored for a later transfer.
Male fertilityEvaluation and care for male fertility, from semen analysis to sperm retrieval and freezing.
Second opinionAnother professional perspective on your diagnosis and previous treatment before your next step.
Questions
Questions about the DFI test
Mon – Sat: 8:30 am – 5:00 pm · Sunday: by prior appointment only · Please contact us in advance to schedule your appointment.
Call +91 73589 75682How is the test done?
It uses a semen sample collected in the same way as for a semen analysis. The sample is processed in the laboratory with a specialised technique that measures DNA damage.
What is a normal DFI?
Laboratories use their own reference ranges, but a lower DFI is generally better. Your specialist will explain your result together with your other tests.
Can a high DFI be improved?
In some men it can. Treating causes such as infection or varicocele, stopping smoking and other lifestyle changes may help, and a repeat test may be advised after a few months.
Does every man need a DFI test?
No. It is a specialised test usually advised in particular situations, such as unexplained infertility, recurrent miscarriage or repeated unsuccessful treatment.
Mon – Sat: 8:30 am – 5:00 pm · Sunday: by prior appointment only · Please contact us in advance to schedule your appointment.
Call +91 73589 75682Book a consultation
Ready to start your journey?
Call us to book a consultation with Dr. Sangeetha Balamurugan. Phone, address and opening hours are below.
Call to book
+91 73589 75682- Hours
- Mon – Sat: 8:30 am – 5:00 pmSunday: by prior appointment onlyPlease contact us in advance to schedule your appointment.
- Visit
- 2nd Floor, Dean Complex, Maris Corner, Thanjavur – 613001, Tamil NaduGet directions